Answer:
when Lady Macbeth says 'Unsex me here'
Explanation:
This clearly shows an act of the supernatural because Lady Macbeth is talking imperatively (commanding them) with the spirits. She wants them to take away her feminine traits and make her man-like so she has the confidence to speak to her husband because in the Jacobean Era (the time they lived there) women had practically no rights and had to obey either her father or her husband. This is why in those time baby boys were preferred.
