Seizures, hypotonia, ataxia, dermatitis, hair loss, ketolactic acidosis, organic aciduria, and prenatal abnormalities are some of the signs and symptoms of biotin deficiency.
Several foods naturally contain the B vitamin biotin, which is also available as a dietary supplement. Despite some dietary biotin being in the free form, the majority of biotin in foods is protein-bound. The protein-bound forms of ingested biotin are broken down by digestive enzymes called proteases and peptidases into biocytin and biotin-oligopeptides. These oligopeptides are then processed by the enzyme biotinidase in the intestinal lumen to liberate free biotin. The majority of the biotin is retained in the liver after being absorbed in the small intestine from the free form or it causes deficiency.
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