Using high-resolution mass spectrometry, where the exact masses rather than the nominal masses are utilized to measure the compound, it is possible to discriminate between each pair of compounds.
Analytes can be detected by high resolution mass spectrometry (HR-MS) to within 0.001 atomic mass units. Time-of-flight (TOF) and Fourier transform ion cyclotron resonance (FTICR), which is the foundation of orbitrap technology, are two examples of HR-MS devices.
Mass spectrometry involves four steps:
Before being introduced into an ionization chamber, the sample is vaporized before being pounded by a barrage of electrons released by a metal coil that has been electrically heated.
It makes use of mass spectrometers with excellent mass accuracy and resolution capabilities. These instruments can be used to determine elemental compositions, identify unknowns, and distinguish between different compounds having the same nominal mass.
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