Some drug-resistant microorganisms were present at the outset of treatment, and their frequency grew due to natural selection.
Bacteria that are resistant to more than one antibiotic are referred to as multidrug-resistant organisms (MDROs for short). Multidrug-resistant organisms are mostly found in hospitals and nursing homes. They frequently affect the elderly or the extremely sick, and they can cause serious infections.
Microbes may also share genes, particularly those that make the bacterium medication resistant. Bacteria reproduce in billions. Bacteria with drug-resistant DNA may pass these genes on to other bacteria. Non-resistant bacteria absorb the additional DNA and develop antibiotic resistance.
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