Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate

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11-08-2022
Biology

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Dosimetric anchoring of in vivo and in vitro studies for perfluorooctanoate and perfluorooctanesulfonate

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tutorconsortium31 tutorconsortium31 · Answer 1 · 2022-08-18T19:18:26+02:00

Dosimetry is required to convert study-specific dose regimens into dose metrics like tissue concentration in order to compare in vivo toxicity studies. In order to possibly uncover mechanisms pertinent to the lowest observable effect level (LOEL) dose group and the commencement of the reported in vivo toxicity, these tissue concentrations may then be compared with in vitro bioactivity experiments.

What is perfluorooctanoate and perfluorooctanesulfonate ?

Due to their ability to withstand both water and oil, the synthetic compounds perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) are utilised as surfactants in a variety of consumer goods and industries.

Avoid paper wrapping, coated cardboard boxes used at fast food restaurants, and food contact paper prepared with grease-resistant coatings. Steer clear of "anti-aging" cosmetics that include PTFE. People who reside in locations where the water supply is PFOA-contaminated ought to think about consuming bottled water.

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