Respuesta :
An important aspect of life is epigenetic memory, which controls how the newly acquired features of cancer- and disease-affected cells are passed from parent to progeny cells as well as the predetermined functional characteristics of normal cells.
"Epigenetic memory gained by priming with osteogenic induction medium improves osteogenesis and other properties of mesenchymal stem cells" Explain this statement.
Under the right circumstances, mesenchymal stem cells (MSCs) are highly malleable cells that can transdifferentiate or dedifferentiate. In the current study, we found that MSCs could be returned to a primitive stem cell population (dedifferentiated osteogenic MSCs, De-Os-MSCs) with improved cell survival, colony formation, osteogenic potential, migratory capacity, and increased expression of Nanog, Oct4, and Sox2, after being in vitro induced to differentiate into bone. The De-Os-MSCs significantly outperformed untreated MSCs in ectopic bone formation in vivo, according to our results, which is the most important finding.
Additionally, Nanog-knockdown in MSCs may undo these improved characteristics in De-Os-MSCs in vitro, demonstrating a crucial function for Nanog in the transcriptional network. Furthermore, the process of de-osteogenic differentiation may be controlled by epigenetic factors such as DNA methylation and histone changes. On the promoters of the Nanog and Oct4 genes, we also discovered reduced methylation and promoter accumulation of activating histone marks such as H3K4me3 and H4ac.
Overall, our research showed that De-Os-MSCs primed with osteogenic induction medium acquired epigenetic memory that favored their differentiation along the osteoblastic lineage with improved cell survival and migratory abilities, which may have potential applications in boosting their regenerative capacity in mammals.
Learn more about epigenetic memory: https://brainly.com/question/14687809
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