Time-Resolved Proteome Analysis of Listeria monocytogenes during Infection Reveals the Role of the AAA Chaperone ClpC for Host Cell Adaptation

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11-08-2022
Biology

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Time-Resolved Proteome Analysis of Listeria monocytogenes during Infection Reveals the Role of the AAA Chaperone ClpC for Host Cell Adaptation

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tutorconsortium205 tutorconsortium205 · Answer 1 · 2022-08-18T18:32:23+02:00

Listeria monocytogenes infection time-resolved proteome analysis indicates the function of the AAA+ chaperone ClpC in host cell adaptability. The set of expressed proteins at a given time, known as the cellular proteome, determines an organism's phenotype under particular circumstances.

What is Listeria monocytogenes?

The pathogenic bacterial species that causes listeriosis is listeria monocytogenes. It is a facultative anaerobic bacterium, meaning it can live with or without oxygen. One of the most dangerous foodborne infections, it may grow and multiply inside the host's cells: High-risk individuals may develop fatal foodborne listeriosis illnesses in 20 to 30 percent of cases.

What conditions are associated with Listeria monocytogenes?

monocytogenes listeria in the US, L. monocytogenes accounts for 2% to 8% of cases of bacterial meningitis and has a fatality rate of 15% to 29%. 48–51 Up to 80% of meningitis cases brought on by this pathogen have been linked to serotypes 1/2b and 4b.

How does listeriosis commonly infect patients?

Listeriosis is a dangerous infection that is frequently brought on by eating contaminated food or by a newborn's potentially fatal sickness. Symptoms in non-pregnant patients frequently include headache.

Learn more about listeria monocytogenes:

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