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Small polar but uncharged molecules like H2O and ethanol,Hydrophobic molecules and gases molecules such as O2 and CO2. These are able too diffuse across the plasma membrane.

Carbon-dioxide and oxygen can diffuse across the plasma membrane, Other need helps to cross its hydrophobic core. Facilitated diffusion molecules diffuse across the plasma membrane , assistance from membrane proteins.

It is the barriers that separating cells from their environment. Integral membrane protein enable ions and large polar molecules to pass through the membrane by passive or active transport. Permeability of phospholipid bi-layer. Gases, hydrophobic molecules and small polar uncharged molecules diffuse through phospholipid bi-layer.

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