Therapies that change genotype
- The substitution of a mutant allele by gene therapy.
Therapies that change phenotype.
- Removing the compromised body portion.
Phenotype:
- An observable characteristic is simply referred to as a "phenotype." Pheno, which has the same root as the term "phenomenon," simply means "observe." It can therefore refer to anything from a common attribute, like height or hair color, to the presence or absence of a disease. It is also an observable type of an organism.
- A person's genotype is their own DNA sequence. This phrase refers more directly to the two alleles a person has for a certain gene. The clinical presentation of a patient is the observable expression of this genotype, or phenotype.
Therapies that change phenotype.
- The replacement of a damaged body with donor tissue.
- Human insulin is used to treat diabetes.
- Lysosomal storage disorder replacement treatment with substitute enzymes.
- Substance abuse counseling.
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