A variety of treatments are available for genetic diseases. Some treatments alter the phenotype. Others alter the underlying genotype. Determine whether each of the treatments listed alters the genotype or the phenotype. Drag each treatment to the appropriate category.

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Therapies that change genotype

  • The substitution of a mutant allele by gene therapy.

Therapies that change phenotype.

  • Removing the compromised body portion.

Phenotype:

  • An observable characteristic is simply referred to as a "phenotype." Pheno, which has the same root as the term "phenomenon," simply means "observe." It can therefore refer to anything from a common attribute, like height or hair color, to the presence or absence of a disease. It is also an observable type of an organism.
  • A person's genotype is their own DNA sequence. This phrase refers more directly to the two alleles a person has for a certain gene. The clinical presentation of a patient is the observable expression of this genotype, or phenotype.

Therapies that change phenotype.

  • The replacement of a damaged body with donor tissue.
  • Human insulin is used to treat diabetes.
  • Lysosomal storage disorder replacement treatment with substitute enzymes.
  • Substance abuse counseling.

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