Acute hepatic necrosis
Acetaminophen (Tylenol) in large doses is extremely hepatotoxic. Patients with normal hepatic function should receive no more than 4000 mg/day. An overdosage of acetaminophen should not result in decreased urinary output, kidney stones, or metabolic alkalosis.
What is Acute hepatic necrosis?
- The clinical course of acute hepatic necrosis mimics an acute, toxic liver injury with a quick and precipitous start, substantial rises in serum aminotransferase levels, and early indications of hepatic (or other organ) dysfunction or failure despite little to no jaundice.
- Hepatocyte death, which can be piecemeal, localised, multifocal, submassive, or massive, is referred to as hepatic necrosis. Massive necrosis refers to necrosis encompassing more than 75% of the parenchymal volume, while submassive necrosis refers to necrosis comprising 26% to 75%.
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