S. aureus can develop resistance to methicillin and other -lactam antibiotics by expressing a foreign PBP, PBP2a, which is resistant to methicillin but can perform the functions of the host PBPs.
Staphylococcus aureus is a Gram-positive round-shaped bacterium that pertains to the Bacillota and is a popular member of the body's microbiota, commonly found in the upper respiratory tract and on the skin.
S. aureus can develop resistance to methicillin and other -lactam antibiotics by expressing a foreign PBP, PBP2a, which is resistant to methicillin but can perform the functions of the host PBPs.
Thus, in this way a non-resistant Staphylococcus aureus bacterium can produce a bacterium that is resistant to methicillin.
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