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How did the Columbian Exchange affect the spread of religions? ... The Columbian exchange helped make Christianity a more global religion. Because Europe forcibly spread Christianity to North and South America, Christianity was able to box out Islam and other religions in the New World. The impact was most severe in the Caribbean, where by 1600 Native American populations on most islands had plummeted by more than 99 percent. Across the Americas, populations fell by 50 percent to 95 percent by 1650. The disease component of the Columbian Exchange was decidedly one-sided.
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