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What are three different defects that could be responsible for malfunctioning lysosomes?

Select the three correct answers.

A) a defect in the synthesis of the glucose-6-phosphate dehydrogenase

B) a defect in the mannose-6-phosphate receptor in the Golgi apparatus

C) a defect in the releasing small molecules from digested materials into the cytosol

D) a defect in a hydrolytic enzyme that breaks down polysaccharide

E) a defect in the process of adding a mannose-6-phosphate signal to lysosomal hydrolases

F) a defect in the mannose-6-phosphate receptor in the mitochondria

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Erudite1
The correct answers are A, D and E. 
Lysosomal malfunctions are always as the result of defective enzymes. Lysosomes are responsible for breaking down of unwanted molecules in the cells. When any of the enzymes which are used by lysosomes is defective, the lysosomes will not be able to perform its function and unwanted materials will build up in the cell leading to various disease. These diseases are called lysosomal disorders.