Hi there!
Here are some career roadblocks that are completely out of your control:
#1 Problems managing stress
#2 Death of loved ones
#3 Losing your job
#4 Accidents putting you in difficult positions (car accidents, stuff like that, etc.)
#5 Your fellow co-workers treating you harshly (though you may try to get them to like you)
These are just a few examples. Hope this helps!