For Q5 and Q6: A child presents with severe neurological defects. Blood tests indicate elevated serum levels of lactate, pyruvate, and alanine. Cultures of skin fibroblasts showed deficient activity of the pyruvate dehydrogenase (PDH) complex. Which of the following conditions can inhibit PDH activity?
1) High ATP
2) High CoA-SH
3) High Acetyl
4) High NADH