An owner has accidentally overdosed their pet with codeine (a weak base, pKa 8.2) so you decide to:_____.
(keeping in mind that pH of the stomach is 3.0, plasma is 7.4, and urine is 8.0)
A. Acidify the urine to increase elimination of the drug.
B. Alkalinize the urine to increase elimination of the drug.
C. Alkalinize the plasma to increase degradation of any remaining drug in the liver.
D. Acidify the stomach to increase degradation of any remaining drug.
E. None of the above would help-weak acids or weak bases are not significantly affected by pH.