Which of the following is not true of the reaction catalyzed by RNA polymerases?
A) Template DNA is copied in the 3' to 5' direction. B) The 3'-hydroxyl group of the growing RNA strand is a nucleophile. C) The reaction is magnesium ion-dependent. D) U residues are incorporated into the RNA to pair with T residues of the template. E) The RNA molecule is synthesized in the 5' to 3' direction.