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11-08-2022
Biology

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Divergent projections of the paraventricular nucleus of the thalamus mediate the selection of passive and active defensive behaviors

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Tutorconsortium322 Tutorconsortium322

21-08-2022

What is Passive and defensive behavior in paraventricular nucleus?

For survival, it's crucial to choose the right passive and active defensive responses when faced with danger.
According to earlier research, active defensive reactions predominantly depend on the nucleus accumbens, whereas passive ones depend on the central nucleus of the amygdala (CeA) (NAc).
It is still unknown what mechanisms enable flexible switching between these two different sorts of reactions.
In mice that the paraventricular thalamus (PVT), in conjunction with the CeA and the NAc, controls the choice of defensive actions.
While the PVT-NAc pathway is blocked during freezing and instead communicates active avoidance events, the PVT-CeA pathway drives conditioned freezing responses.

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